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In people with reduced ALDH2 levels (and thus more acetaldehyde), alcohol is more likely to induce asthma.[ref] One study explains: Impaired ALDH2 activity leads to high peak levels of acetaldehyde and to histamine release. Studies show that inhaling acetaldehyde induces histamine-mediated airway constriction, such as is seen in asthma.[ref] Hangovers and histamine A recent animal study sheds light on the age-old question of what causes hangover symptoms

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10.1146/annurev.med.51.1.357 [DOI] [PubMed] 4.Green R, Allen LH, Bjrke-Monsen AL et al (2017) Vitamin B12 deficiency

This antagonism between noncanonicalWnt/Ca 2+ and canonical Wnt/-catenin signalling pathways is successfully covered in our reconstructed network