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Discontinuation, regain, and reinitiation (class-level, semaglutide / tirzepatide) Budini 2026 ( eClinicalMedicine ) pooled regain curve: asymptotic maximum regain 75.3% of lost weight, half-life about 23 weeks, so roughly 60% of the loss returns by 12 months and about 40% is still held at a year
Svensson, J., et al

Factors like cardiovascular concerns, sleep apnea, or prior reactions to hormone therapy can influence both the starting dose and how closely therapy is monitored

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