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In contrast, local delivery strategies, including intrathecal and direct local injection, bypass the BSCB and substantially enhance local bioavailability

TRANSCRIPTIONAL UP-REGULATION OF NRF2 GENE BY ONCOGENE-DEPENDENT SIGNALING Because the degradation process primarily regulates the level of Nrf2 protein, there have been a few studies concerning the transcriptional control of the Nrf2 gene

[DOI] [PubMed] [Google Scholar] 25.Doran GR

According to the well-established ascorbate-glutathione cycle in biochemistry, ascorbic acid (vitamin C) directly regenerates oxidised glutathione (GSSG) back to its active reduced form (GSH)