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In patients with RF, plasma concentrations of the cytokines TNF, interleukin IL-6, and IL-8 were measured as sharply increasing at 24 hours after penicillin treatment when patients were experiencing a JHR, with a return toward baseline levels 12 hours after therapy (Figure 1 )

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To combat binder-induced constipation, patients are often advised to vastly increase their water intake, consume adequate dietary fiber, and utilize targeted supplements like magnesium citrate, vitamin C, or specialized prokinetics to keep the bowels moving

Zhou HL, Tan KCB, Shiu SWM, Wong Y