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Description
Those with Severe Kidney Disease: The medication can potentially worsen kidney function in some cases

Glutamine deprivation impairs function of infiltrating CD8+ T cells in hepatocellular carcinoma by inducing mitochondrial damage and apoptosis

Biochim Biophys Acta 1787 : 13831394 Kriaucionis S, Paterson A, Curtis J, Guy J, Macleod N, Bird A 2006 Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome

This implies that deviations from mitochondrial homeostasis manifest differently and have varying consequences across cell types
