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Apart from the well-documented GPx-like catalytic activity, ebselen is also reported for directly scavenging the biologically relevant ROS (like peroxyl and singlet oxygen) and reactive nitrogen species (peroxynitrite) with rate constants comparable to standard antioxidants

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Antioxid Redox Signal 27(15):11621177 Carretero J, Obrador E, Anasagasti MJ, Martin JJ, Vidal-Vanaclocha F, Estrela JM (1999) Growth-associated changes in glutathione content correlate with liver metastatic activity of B16 melanoma cells