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Patients with the disease develop multiple hamartomatous intestinal polyps and have an increased likelihood of developing malignancies in multiple sites including the gastrointestinal tract, breast, thyroid, ovaries, testicles and pancreas [1, 5, 8, 15]

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These trophic hormones exert both acute effectssuch as rapid stimulation of StAR-dependent cholesterol transportand chronic effects through transcriptional upregulation of steroidogenic enzymes

With these considerations, a proper understanding of the interconnection between tissues, cellular subcompartments, and membrane transporters in carnitine traffic is needed to realize the possible role of carnitine in cancer