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The therapeutic window is longer than the pharmacokinetic half life because receptor occupancy and downstream signaling persist after plasma levels fall below detectable thresholds

Analyzing such information for research and development of new technologies

F.XuQ.ChenM.PengW.et al (2013)

If CMS determines that the requesting hospital meets the criteria for an applicable hospital or high Medicaid facility, CMS would then decide whether to approve or deny the expansion exception request
