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The therapeutic window is longer than the pharmacokinetic half life because receptor occupancy and downstream signaling persist after plasma levels fall below detectable thresholds

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Analyzing such information for research and development of new technologies

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F.XuQ.ChenM.PengW.et al (2013)

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If CMS determines that the requesting hospital meets the criteria for an applicable hospital or high Medicaid facility, CMS would then decide whether to approve or deny the expansion exception request

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