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Suppression of the SLC7A11/glutathione Axis Causes Synthetic Lethality in KRAS-Mutant Lung Adenocarcinoma

Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD

OAT4 is identified as an apical transporter in proximal tubule cells and only expressed in advanced primates, including humans ( Function of OAT4 ( SLC22A11 ) In addition to uric acid, OAT4 also promotes the absorption of high-affinity binding steroids such as estronesulfate (ES) or dehydroepian drosterone sulfate (Roch-Ramel et al., 1994

These processes include the creation of ROS, disruption of mitochondrial function, and the activation of necrotic/apoptotic pathways, ultimately resulting in permanent excitotoxic damage to the neurons