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Senescence is a state in which a cell permanently exits the cellcycle (no longer divides) in response to stress such as DNA damage, telomere shortening, oncogene activation, oxidative stress, or replicative exhaustion

Because angiogenesis is a defining hallmark of tumor growth and metastatic progression, any therapeutic agent that enhances neovascularization could, in theory, facilitate tumor expansion and promote metastatic dissemination

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