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A confirmed B12 deficiency is diagnosed through a blood test measuring serum B12 levels, along with tests for MMA and homocysteine, which become elevated in deficiency cases
Two kinds of histone lysine methyltransferase, histone-lysine N -methyltransferase 2A (corresponding gene: MLL1 ) [159], and histone-lysine N -methyltransferase EHMT2 (corresponding gene: G9a ) [160], respectively, catalyze the chemical reaction as below with different products, H3K4 and H3K9: One recent study reported the kinetic constants for histone-lysine N -methyltransferase EHMT2 (G9a): the Km value of G9a for SAMe was 0.53 0.043 M
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doi: 10.1007/s10787-017-0309-4 42 JiaY.WangX.LiL.LiF.ZhangJ.LiangX
