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Investigators proceeded with supplementation with folic acid (350 to 1,000 g daily by mouth) and vitamin B12 (1,000 g IM every 9 weeks) in 220 patients receiving chemotherapy with pemetrexed disodium
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They are also used by children with minimal brain dysfunction syndrome [28,29] and patients with encephalopathy [30], and their effect on myalgic encephalomyelitis (chronic fatigue syndrome) has also been tested [31]
