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This means cleaner data, clearer interpretation, and fewer wasted experimental cycles

however, it has been shown that if the appropriate management is implemented promptly, poisoning with a much higher dose of nearly 7 mL/kg (920 mg/dL) can be successively treated (Martens et al

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Intranasal administration of the optimized formulation (Cmax = ~ 600 ng/mL, tmax = 0.5 h) exhibited a plasma AUC 0.78 times the AUC of the orally administered product (Cmax = ~ 780 ng/mL, tmax = 2 h), whereas the brain AUC was significantly (3.28 times) higher for intranasal administration (Cmax = ~1240 ng/mL, tmax = 0.5 h) than oral administration (Cmax = ~ 380 ng/mL, tmax = 1 h)