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On the other hand, SOD2 itself has the potential to activate NF-B signalling pathways 46

10.21037/tcr-24-107 101 ShengD.JinC.YueK.YueM.LiangY.XueX.et al

Thiol groups are strong reducing agents thus glutathione serves as an electron donor and in the process is converted to its oxidised form

[ 239 ] In another study, transcriptomic data was analyzed to develop a mechanismbased gene regulatory network, revealing that Raf kinaseB inhibitor protein (RKIP) and BACH1 belong to two antagonistic teamsBACH1 driving the promotion of EMT, stemlike, and therapyresistant cell states, while RKIP enabling the promotion of epithelial, less stemlike, and therapysensitive phenotypes