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Description
Figure 2 Another crucial component of nutraceutical function is immune response modulation

296,297,298 The pivotal function of CXCR1 in resistance to infection was demonstrated in humans harboring a variant of the CXCR1 gene, which correlated with heightened susceptibility to bacterial infections

Upon changes in mitochondrial function, retrograde signaling pathways are activated to coordinate mitochondrial protein synthesis during biogenesis but also to communicate eventual mitochondrial malfunctions, triggering compensatory responses in the nucleus (232)

The biggest concern when dealing with the MTHFR gene mutation is a vitamin B deficiency
