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Description
By enhancing the stability of antigen peptide-MHC complexes and the intensity of co-stimulatory signals, it effectively improves the capacity of DCs to activate T cells (79)
Indeed, several nuclear antigens that bind to CRP are the same as those targeted by Antinuclear Antibodies (ANA) seen in the sera of SLE patients or others with systemic inflammatory rheumatic diseases

Levels are frequently high in adult-onset Stills disease and systemic lupus erythematosus (SLE), and they correlate with disease activity
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