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Lancet 1995;346:1080-4

Notably, ROS play a subtle double-edged sword role in male reproductive physiology: while physiological levels of ROS are essential signaling molecules for normal fertilization processes such as sperm capacitation, hyperactivation, and the acrosome reaction (6971), in the pathological microenvironment of CP, this delicate balance is thoroughly disrupted

These biochemical processes explain why most NAD+ side effects don't last long
