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Tirzepatide, in contrast, may address the root cause: metabolic dysfunction
Hyperphosphorylation of the Rabs disrupts their interaction with GTP/GDP exchange factors (GEFs), and Rab GDP dissociation inhibitors (GDIs), resulting in their inactivation and membrane-cytosol redistribution (Steger et al., 2016)

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What pathway anaerobically generates energy in the form of ATP