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NLRP3 senses a wide array of endogenous and exogenous danger signals, including microbial products, environmental toxins, and host-derived DAMPs, making it a central player in inflammatory responses

For the beads assays, the fluorescein-labeled oligonucleotides from the library and from rounds 3, 7, 9, and, 12 were heated to 95 C for 10 minutes and rapidly cooled to 4 C, then incubated at room temperature

It is important to emphasize that although certain research progress has been made, our work is still at the preclinical stage and remains some way from clinical application
