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An additional, 11 non-herniated human discs were used to examine causality: half of each specimen was cultured in a manner that allowed free unconstrained swelling (similar to a herniated disc in vivo), while the other half was cultured within a perspex ring that allowed constrained swelling

1991 Mar;53(3):695-7

Patients with gastrointestinal disorders, such as Crohns disease, celiac disease, or those who have undergone gastrointestinal surgeries like bariatric surgery, may also find B12 injections advantageous

Past Covid patients on adverse reaction sites I follow seem to have more trouble with s/e due to their immune systems already being fully ready to defend against Covid