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This transformation facilitated tumour cell uptake and site-specific unloading of siRNA within lysosomes via protonation-induced release [21]
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In addition, there are a few microorganisms with both of the C4 and C5 pathways, such as Euglena gracilis (Weinstein and Beale 1983)
Recently, there has been a great improvement in assay methods and measurement accuracy for biomarkers of oxidative stress, which have been correlated with disease activity and progression of disease, however this has not been validated in the clinic
