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Appropriate maternal folic acid intake is essential to the fetus during pregnancy, and no problems with maternal supplementation to achieve adequate intake goals are known

This means that hydroxycobalamin stays in the body for longer periods of time and can provide sustained levels of vitamin B12, which may be beneficial for individuals with severe or chronic vitamin B12 deficiency

Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes
