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44 SIRT6 promotes genes associated with collagen production, 45 and both SIRT1 and SIRT6 mediate the inhibition of MMP-1 gene transcription, which degrades collagen

Figure 4 PPAR Activity Involves in Altered DC Differentiation in MEHP-Treated FL-DCs As DEHP is rapidly metabolized to MEHP, a major metabolite in the serum ( - populations, including late DC progenitors (CD11c + MHC class II - ), differentiating DCs (CD11c + MHC class II + ), and CD11c - subset (CD11c - MHC class II - and CD11c - MHC class II + ) ( Figure 4D )

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