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Small Molecule Insulin-Regulated Aminopeptidase Inhibitors From In Silico Screening In 2008, Siew Chai and her group in Australia disclosed the first generation of drug-like small molecular weight inhibitors of IRAP ( in silico screening of a homology model of IRAP based on the crystal structure of LTA4H (Leukotriene-A4 hydrolase) was applied (Thunnissen et al., 2001)

These experiments have been done using different common models "in vitro" and "in vivo"

Journal of Applied Physiology , 110 (3), 774780

Worth mentioning, as Selyes stress concept (Selyes stress response against various noxious agents to reestablish homeostasis) [31,32] gave birth years later to Roberts cytoprotection concept [16,17] (for review see, i.e., [33]), the cytoprotection concept holds a response that is specifically related to prevent or recover damage as such