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It is possible that circulating IGF-II after release from the ternary complex is cleared from the circulation by binding to the IGF2R identical to the mannose-6-phosphate receptor which is associated with lysosomes and results in degradation of IGF-II in endothelial cells (23)

Seitz et al., 2013

As consumer awareness of the skin barrier has grown dramatically in recent years, products designed to support barrier stability have become extremely popular
