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The etiology of ALS remains largely elusive in the majority of cases, with fewer than 10% attributed to specific genetic mutations involving genes such as SOD1, C9orf72, TDP43, and FUS (78)

Experimental design In the autumn season of 2022, a pot experiment was done at Helwan University's Experimental Farm in Cairo

The non-enzymatic antioxidant system functions along with an enzymatic system to counteract the negative effect of ROS in plants

This model recapitulates important features of human ALS including the degeneration of spinal motor neurons, muscle weakness, and paralysis, as well as histological features such as pathological inclusions in neurons and glia, some of which contain mutant Sod1 (Stieber et al., 2000
