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Notably, a large portion of the leptin AB loop (residues 2439), including the region implicated in the site 3B interaction, is disordered in the crystal structure apo-leptin, but ordered upon LepR binding (Fig

Individual variability depends partly on genetics, baseline metabolic health, and nutritional status

Covers: biochemistry of amylin, receptor biology (CTR + RAMP complex), physiological functions, clinical applications, the Pramlintide experience, perspectives for long-acting analogs

Vilstrup H, Amodio P, Bajaj J, Cordoba J, Ferenci P, Mullen KD, et al
