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The use of Optifolin+ rather than standard folic acid is clinically significant: up to 40% of people have MTHFR polymorphisms that impair folic acid conversion, and folic acid supplementation may be largely ineffective for COMT-dependent methylation in this population.*

Gonzalez MT, Kirkevold M (2014) Benefits of sensory garden and horticultural activities in dementia care: A modified scoping review

This unique behaviour of glycated proteins also explains the strong clinical correlation between chronic hyperglycemia and susceptibility to neurodegenerative disorders

Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons