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Description
These include oral leptin mimetics and intranasal leptin, both of which are in preclinical stages of drug development [15,45,46]
The classical somatomedin hypothesis (Salmon and Daughaday, 1957, foundational sulfation factor research) assumed all peripheral IGF-1 came from this hepatic source
Clinical Evidence 2026 Update: Phase 3 TRIUMPH Data In December 2025, Eli Lilly reported the first successful Phase 3 readout for retatrutide (LY3437943) from the TRIUMPH-4 trial
doi: 10.1183/09031936.01.17303950
