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Mechanistic Signals Paint an Intriguing Picture, But Only in Rodents BPC-157 activates several pro-healing pathways in animals: VEGF-driven angiogenesis , improving local microvascular density (Park, 2025) Nitric oxide signaling , important for microcirculation and tissue recovery (Park, 2025) Fibroblast survival and migration , key for tendon and ligament healing (Park, 2025) Suppression of inflammatory cytokines such as IL-6 and TNF- (Park, 2025) Taken together, BPC-157 acts like a biological conductor in rodents, nudging multiple systems toward regeneration