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Gene therapies to upregulate specific isoforms and biomarkers for early detection are also on the horizon, aiming for personalized interventions

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In order to have a better understanding of ROS testis neutralization or limitation by the antioxidant systems, we summarize the major pathways of ROS generation and the mechanistic antioxidative defense in Figure 1

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Mycothiol Actinomycetes, such as Mycobacteria, Corynebacteria, and Streptomyces, synthesize the cysteinyl pseudo-disaccharide mycothiol (MSH) as major LMW thiol [47]

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10.3390/ijms22095010 63

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