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Thus it is difficult to establish a baseline for the symptoms over a longer observation period

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Dietary intake of micronutrients, such as folates and amino acids, directly contributes to OCM, thereby adapting the cellular metabolic state to environmental inputs

Age-related changes in cerebral microcirculation include impaired neurovascular coupling (NVC) [124,127,129,132,134,136,137,138,139,141,142,143,144,145,146,147,148,149,150], bloodbrain barrier disruption [123,124,127,128,129,131,135,136,141,146,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166], dysregulation of cerebral blood flow (CBF), endothelial dysfunction [141,167], endothelial senescence [168,169,170,171,172,173,174,175,176], microvascular rarefaction [128,177], and chronic low-grade microvascular inflammation [164,178,179]