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*Correspondence: Isabelle Boileau [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Discovery of ML210-Based Glutathione Peroxidase 4 (GPX4) Degrader Inducing Ferroptosis of Human Cancer Cells

These naturally occurring substances-such as polyphenols (e.g., curcumin, resveratrol), omega-3 fatty acids (e.g., DHA, EPA), and sulforaphane from cruciferous vegetables exert antioxidant, anti-inflammatory, anti-apoptotic, suppression of ferroptosis, and neuroprotective effects that help limit secondary brain damage and support neural regeneration

GSH plays a role in amino acid transport, protein synthesis, DNA synthesis and protection, and more generally, in cellular detoxification