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The trial was designed to enroll 1,200 patients but closed to accrual early (after 824 evaluable patients had enrolled) once the results of the nelarabine randomization on AALL0434 were released.[20] Comparing patients with T-ALL assigned to receive bortezomib versus patients who did not receive bortezomib, there was no difference in the 4-year EFS rate (82.9% vs

10.1002/fsn3.1015 42 MahajanS

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Cells were cultured in EMEM (Eagle Minimum Essential Media, Sigma-Aldrich) supplemented with 10% FBS (Gibco), 200 mM L-glutamine (Sigma-Aldrich), 1% NEAA (Sigma-Aldrich) and maintained at 37 C, 5% CO 2