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Microsomal triglyceride transfer protein (MTTP) expression, essential for VLDL assembly, is also reduced in NAFLD, often in parallel with downregulation of apolipoprotein B (ApoB)both of which are critical for efficient hepatic lipid export

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Alterations in mitochondrial dynamics lead to a range of metabolic abnormalities: impaired oxidative phosphorylation, defective mitochondrial gene expression, imbalances in fuel and energy homeostasis, increased ROS production, enhanced insulin resistance, and abnormal FA metabolism