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In addition, mitochondrial dysfunction in stromal cells is the key causal factor triggering fibrosis-induced ovarian decline, and metformins reversal of ovarian fibrosis converges on related mitochondrial metabolic pathways that are upstream of oxidative stress and inflammation (Umehara et al., 2022)
H3K9 trimethylation dictates neuronal ferroptosis through repressing Tfr1
For instance, it is demonstrated that GSTA played an essential role in the detoxification of chlorambucil via catalyzing the GSH conjugation reaction of this alkylating reagent [104]
