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Due to low solubility of riboflavin in neutral aqueous solvents, part of the fermentation product accumulates as needle-like crystals in the broth, which can be easily separated from the biomass by centrifugation or filtration

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gradual reperfusion or postconditioning techniques, which modulate flow restoration to reduce microvascular injury [172, 180, 230, 252], and selective intracoronary hypothermia [140, 171, 184], which maintains the myocardial temperature below core temperature during reperfusion to limit IRI

References Alaggio R, Amador C, Anagnostopoulos I, et al.: The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms