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Through the regulation of glutamate and GABA, glutamine within the CNS plays an integral role in many aspects of neurobiology and as such disturbances in glutamine metabolism and/or transport have been implicated in a range of pathologies ranging from chronic stress, epilepsy, hepatic encephalopathy, manganese encephalopathy, neurodegenerative disorders and metabolic disease (Reference Huang, Liu and Yin54,Reference Ivens, Caliskan and Papageorgiou55)
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For T2D (Ozempic), escalation goes from 0.25 mg to 0.5 mg, then optionally to 1 mg and 2 mg
10.1074/JBC.R117.800169 [DOI] [PMC free article] [PubMed] [Google Scholar] Suzuki T, Takahashi J, Yamamoto M (2023) Molecular basis of the KEAP1-NRF2 signaling pathway
