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As an example of the latter, the re-salvaging from dihydrobiopterin of tetrahydrobiopterin, an essential cofactor in trace amine and catecholamine neurotransmitter synthesis and nitric oxide production, is rate limited by provision of the enzyme dihydrofolate reductase produced by the folate cycle [36,37]

Sleep disturbance in children with growth hormone deficiency
G.BannantineJ
This pattern mirrors how regulators like NAD are tracked across aging, mapping core metabolic players in detail long before they become medicines
