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Author contributions LC performed the experiments, contributed to experimental design, analyzed data and wrote the manuscript

Stages of knee OA progression include: Early stage , marked by cartilage softening, bone marrow lesions and mild synovits

B12 INJECTION Vitamin B12 is a nutrient that helps keep our bodies healthy

HDACi was shown to inhibit the maturation process of dendritic cells, thereby affecting their ability to present antigens
