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Yes, split dosing is a valid approach, particularly for doses at the higher end of the range (450-500mcg daily)

The acidified environment adds positive charge to the peptide, and that shared charge creates electrostatic repulsion between molecules

5-Amino-1MQ was identified as a potent NNMT inhibitor in work published by the Bhatt Lab and collaborators, with subsequent preclinical studies demonstrating that NNMT inhibition in diet-induced obese mice reduced body weight, decreased adipose tissue mass, and improved metabolic parameters including insulin sensitivity and plasma lipids

If it has a role, its more like a supporting actor than a lead therapy