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Semaglutide: GLP-1 receptor agonist activating Gs-cAMP-PKA signaling for glucose- dependent insulin secretion, central appetite suppression, and delayed gastric emptying

While p53 modulators, including FOXO4-DRI, MDM2 inhibitors, and USP7 inhibitors have shown senolytic effects by selectively eliminating senescent cells or promoting their apoptosis in the laboratory, translating these findings to the clinic have so far been unsuccessful