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Studies also demonstrated that berberine sensitizes drug-resistant breast cancer cells to doxorubicin by the modulation of the AMPK-HIF-1 -P-gp pathway [214]
doi: 10.1111/jnc.14033
J.MengF
Similarly, activation of oncogenes such as KRAS , MYC , MDM2 and NRF2 10,17,18,19 can lead to an increase in SSP enzyme expression, also allowing cells to become resistant to depletion of exogenous serine
