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The anatomical distribution of dopaminergic neurons is well circumscribed within the brain

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The DNA receptor was prepared by removing water molecules, building in missing hydrogen atoms, and assigning atomic charges

The substitution of carboxamide at the alkyl terminal (KL2, KL4 and KL5) or removal of the nitrile group from the dihydropyridine ring (KL6) moderately reduced their adjuvant activity (Extended Data Fig