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Among which, C677T and A1298C polymorphisms of MTHFR have been studied the most in psychiatric diseases and showed significant association with reduction of MTHFR enzymatic activity and methylation
By aligning microbial gene expression involved in SCFA and bile acid metabolism, it coordinates nutrient handling with hormonal rhythms
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Histone marks like H3K4me3 and H3K9ac remain enriched at antioxidant loci after stress, facilitating rapid transcriptional reactivation
