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Bhattacharjee et al., 2021), has recently been found to exhibit anatomical connectivity with the heart (Li et al., 2021), Optogenetic experiments demonstrate that activating M1 glutamatergic neurons bidirectionally modulates heart rate and contractile function in both healthy and myocardial infarction (MI) mice (Bo et al., 2024)

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VPS35 BioID1 proximity labelling, followed by targeted western analysis confirmed the selectivity of labelling for these proteins within the Retromer sub-domain (Fig