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Distinct variabilities of infection rates, epidemiological transmission, and clinical outcomes during COVID-19 pandemic raises an intriguing question, whether the emergence of SARS-CoV-2 variants of concern (VOCs) with function-specific mutations in ACE2, furin, and TMPRSS2 expression has played any role in disease manifestations and case fatality rates (CFR) 55,75

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Most remarkably, for almost all bacterial isolates, 30 mM GSH was shown to enhance antibiotic efficiency, indicating the practicality of GSH in treatment of biofilm-associated infections (Figure 2)

Briefly, pellets from the bacterial culture were resuspended in periplasmic extraction buffer (100 mM Tris/Cl pH 8.0, 0.5 M sucrose, 1 mM EDTA), incubated for 30 min at 4 C, and centrifuged repeatedly to remove the spheroplasts