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Typical neonatal or infantile presentation of pyruvate dehydrogenase complex deficiency is characterized by hypothermia, respiratory distress or failure, vomiting, metabolic and lactic acidosis, delayed motor development, poor linear growth or weight gain, intellectual disability, speech delay, and neurologic findings (eg, lethargy, apathy, hypotonia, pyramidal and extrapyramidal signs, ataxia, or seizures)

Our identification of VRK2-mediated SLC7A11 trafficking suggests a potential immune evasion mechanism, as SLC7A11-high tumors often display T cell exclusion phenotypes [37], warranting future investigation into whether VRK2 expression could predict therapeutic response to combined ferroptosis inducers and immune checkpoint inhibitors

Although existing data are promising, rigorous randomized controlled trials are still needed to confirm whether riboflavinalone or combined with agents like magnesium or glutathione precursorsimproves functional outcomes in TBI and stroke

Effects of different dietary selenium sources on growth performance, liver and muscle composition, antioxidant status, stress response and expression of related genes in gilthead seabream ( Sparus aurata )