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Peroxynitrite blocked the activation of Akt in macrophages (536), adipocytes (949), PC12 cells (1148, 1193), and endothelial cells (353, 485487, 1471), through a mechanism involving nitration and inactivation of phosphatidylinositol 3-kinase, the upstream signaling intermediate in the Akt pathway (353, 536)
Available at: PMC Lall S, et al
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