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Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators

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In this review, we discuss the phenomenon of ADE, its possible mechanism that may play a significant role in the pathogenesis of COVID-19 by relating the previous and some current findings with the COVID-19 pandemic and highlights the interplay of antibodies that may be neutralizing or non-neutralizing in nature with viral surface receptors that may lead to this condition